Corey A. Smith, PhD
Assistant Professor
QEII Foundation Scholar in Retina Research
Department of Ophthalmology and Visual Sciences, Dalhousie University
Affiliate Scientist
Nova Scotia Health
PubMed
ORCID
LinkedIn
Research Interests
The goal of my research program is to conduct retinal research in a collaborative and innovative environment with the goal of improving patient care. Two important priorities are: 1) creating a diverse research group with multidisciplinary collaborations, and 2) conducting research that is a balance of experimental methods and clinical relevance.
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Retinal Imaging
The eye is a complex organ that contains central nervous system tissue, but also remarkably accessible to view and study non-invasively.
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Image Interpretation
Novel methods for image analysis, especially 3D data, can provide new understanding of retinal diseases and be used for artificial intelligence.
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Clinical Data
Answering research questions with a combination of administrative and clinical records from hospital databases and chart reviews.
Current Projects
- Clinical Epidemiology of Retinal Detachments
- Biomechanics of the Human Retina
- Improving Diagnostic Utility of Retinal Imaging
Team
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Brianna Samson
Masters Student - Biomedical Engineering
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Colyn Munn
PhD Student - Biomedical Engineering
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Korolos Sawires
Research in Medicine (RIM) Student
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Patient Partners (coming soon)
Publications
2026
- Samson BE, Nashnoush MH, Smith CA. Biomechanics of the retina: experimental and clinical perspectives. Biomed Eng Online 2026 In press. https://doi.org/10.1186/s12938-026-01599-2
- Munn C, Kamintsky L, Serlin Y, Smith CA, Friedman A, Corredores J, Levy J. Link between baseline peripheral vascular leakage and treatment response in patients with central retinal vein occlusion: A pilot study. Clin Ophthalmol 2026;20:579250. https://doi.org/10.2147/opth.s579250
2025
- Rhyno EM, Alim SI, Matheson KJ, Gupta RR, Dickinson JD, Samad A, O'Brien DM, Smith CA. Rhegmatogenous retinal detachment in Canadian population: a retrospective cohort study examining incidence and risk factors. Can J Ophthalmol 2025 Jun;61(3):575-581. https://doi.org/10.1016/j.jcjo.2026.01.011
- Hodgson K, Palakkamanil MM, Zhang A, Dyachok OM, Smith CA, Nicolela MT, Chauhan BC. Effect of ginkgo biloba extract on macula and peripapillary perfusion examined using optical coherence tomography angiography. Can J Ophthalmol 2025 Aug;60(4):e566-e571. https://doi.org/10.1016/j.jcjo.2025.01.015
2024
- Tomita R, Smith CA, Dyachok OM, Sharpe GP, Rafuse PE, Shuba LM, Nicolela MT, Chauhan BC. Sequence and detectability of changes in macular ganglion cell layer thickness and perfusion density in early glaucoma. Invest Ophthalmol Vis Sci 2024 Dec 2;65(14):8. https://doi.org/10.1167/iovs.65.14.8
- Smith CA, Josey VL, West ME, Dyachok OM, Sharpe GM, Vianna JR, Rafuse PE, Shuba LM, Nicolela MT, Chauhan BC. Variability of scan quality and perfusion density in longitudinal optical coherence tomography angiography imaging. Br J Ophthalmol 2024 Jun 20;108(7):978-983. https://doi.org/10.1136/bjo-2022-322979
- Pollmann AS, Pinto AM, Cadieux D, Seamone CD, George SP, Smith CA, Leiws DR. Association Between Indication for Descemet Stripping Automated Endothelial Keratoplasty and Rural Residency. Cornea 2024 Mar 1;43(3):349-355. https://doi.org/10.1097/ico.0000000000003347
2023
- Eadie BD, Mishra AV, Betsch DM, Smith CA, Nicolela MT, Chauhan BC. Transsynaptic vascular hypoperfusion in the retina of a patient with post-chiasmal lesion and homonymous hemianopia. J Neuroophthalmol 2023 Dec 1;43(4):e349-e351. https://doi.org/10.1097/wno.0000000000001733
- Ruparelia S, Orr S, Choudhry N, Wong RW, Smith CA, Taylor SM, Gupta RR. Risk for surgical team hearing loss with vitrectomy. J Vitreoretin Dis 2023;Sept-Oct;7(5):397-403. https://doi.org/10.1177/24741264231172564
2022
- Di Pierdomenico J, Henderson DCM, Giammaria S, Smith VL, Jamet AJ, Smith CA, Hooper ML, Chauhan BC. Age and intraocular pressure in murine experimental glaucoma. Prog Ret Eye Res 2022 May;88:101021. https://doi.org/10.1016/j.preteyeres.2021.101021
2021
- Hirasawa K, Smith CA, West ME, Sharpe GP, Shuba LM, Rafuse PE, Nicolela MT, Vianna JR, Chauhan BC. Discrepancy in loss of macular perfusion density and ganglion cell thickness in early glaucoma. Am J Ophthalmol 2021;221:39-47. https://doi.org/10.1016/j.ajo.2020.08.031
2012–2020
- Duggan E, Smith CA, Hooper ML, Chauhan BC. Colocalization of optical coherence tomography angiography with histology in the mouse retina. Microvasc Res; Published Online First: 8 August 2020. https://doi.org/10.1016/j.mvr.2020.104055
- Hanna V, Sharpe GP, West ME, Hutchison DM, Shuba LM, Rafuse PE, Nicolela MT, Smith CA, Chauhan BC. Peripapillary retinal segmentation in optical coherence tomography angiography. Ophthalmology 2020;127(12):1770-1772. https://doi.org/10.1016/j.ophtha.2020.05.032
- Smith CA, West ME, Sharpe GP, Hutchison DM, Shuba LM, Rafuse PE, Nicolela MT, Chauhan BC. Asymmetry analysis of macular optical coherence tomography angiography in patients with glaucoma and healthy subjects. Br J Ophthalmol 2020;104(12):1724-1729. https://doi.org/10.1136/bjophthalmol-2019-315592
- Smith CA, Hooper ML, Chauhan BC. Optical coherence tomography angiography in mice: Quantitative analysis after experimental models of retinal damage. Invest Ophthalmol Vis Sci 2019;60(5):1556-1565. https://doi.org/10.1167/iovs.18-26441PDF of this article
- Smith CA, Chauhan BC. In vivo imaging of adeno-associated viral vector labelled retinal ganglion cells. Sci Rep 2018;8:1490. https://doi.org/10.1038/s41598-018-19969-9PDF of this article
- Smith CA, Vianna JR, Chauhan BC. Assessing retinal ganglion cell damage. Eye 2017;31(2):209-217. https://doi.org/10.1038/eye.2016.295PDF of this article
- Smith CA, Chauhan BC. Imaging retinal ganglion cells: Enabling experimental technology for clinical application. Prog Retin Eye Res 2015;44:1-14. https://doi.org/10.1016/j.preteyeres.2014.10.003
- Smith CA, Newson TA, Hutnik CML, Hill KA. Identification of anomalous features of intravitreal injections using micro-computed tomography. Curr Eye Res 2013;38:375-380. https://doi.org/10.3109/02713683.2012.744059
- Smith CA, Newson TA, Leonard KC, Barfett J, Holdsworth DW, Hutnik CML, Hill KA. A novel framework for modeling ocular drug transport and flow through the eye using micro-CT. Phys Med Biol 2012;57(19):6295-6307. https://doi.org/10.1088/0031-9155/57/19/6295
Support
Contact
Address
Department of Ophthalmology & Visual SciencesQEII Health Sciences Centre
2035-2 West Victoria, 1276 South Park St.
Halifax, Nova Scotia, Canada B3H 2Y9