COREY A. SMITH, PhD

Doctor of Philosophy in Physiology and Biophysics

2011 - 2017

Department of Physiology and Biophysics, Dalhousie University, Halifax, Nova Scotia, Canada

Master of Engineering Science in Biomedical Engineering

2009 - 2011

Biomedical Engineering Graduate Program The University of Western Ontario, London, Ontario, Canada

Bachelor of Medical Science, Honours in Medical Biophysics

2004 - 2008

Schulich School of Medicine & Dentistry and the Faculty of Science, The University of Western Ontario, London, Ontario, Canada

The eye is a complex organ that contains central nervous system tissue, but also remarkably accessible to view and study. It can be used as a window into the human body and a means of detecting ocular diseases, in addition to diabetes, heart disease, cancer and multiple sclerosis. My experience and understanding of biophysics, engineering and physiology provide me with the opportunity to approach vision and eye research problems from a unique perspective. Two important priorities for my research projects are:

1. Research that is a balance of experimental methods and clinical relevance
2. Multi-disciplinary collaborations and approaches to assist in answering important questions

The research area in which I am most enthusiastic is non-invasive imaging for disease detection and prevention. I have utilized a variety of imaging techniques in my previous and current work including microscopy (light, fluorescence, intravital video), micro-computed tomography, scanning laser ophthalmoscopy and optical coherence tomography. My current research is investigating the variability of optical coherence tomography angiography and developing reliable quantitative measures from the acquired data. Developing new tools and methods for non-invasive imaging of the eye is required for accurate longitudinal results and to obtain a better understanding of disease progression.

Keywords: retinal ganglion cells, in vivo imaging, ocular drug delivery, digital image processing, image analysis

Hirasawa K, Smith CA, West ME, Sharpe GP, Shuba LM, Rafuse PE, Nicolela MT, Vianna JR, Chauhan BC. Discrepancy in loss of macular perfusion density and ganglion cell thickness in early glaucoma. Am J Ophthalmol; Published Online First: 20 August 2020. https://doi.org/10.1016/j.ajo.2020.08.031

Duggan E, Smith CA, Hooper ML, Chauhan BC. Colocalization of optical coherence tomography angiography with histology in the mouse retina. Microvasc Res; Published Online First: 8 August 2020. https://doi.org/10.1016/j.mvr.2020.104055

Hanna V, Sharpe GP, West ME, Hutchison DM, Shuba LM, Rafuse PE, Nicolela MT, Smith CA, Chauhan BC. Peripapillary retinal segmentation in optical coherence tomography angiography. Ophthalmology; Published Online First: 19 May 2020. https://doi.org/10.1016/j.ophtha.2020.05.032

Smith CA, West ME, Sharpe GP, Hutchison DM, Shuba LM, Rafuse PE, Nicolela MT, Chauhan BC. Asymmetry analysis of macular optical coherence tomography angiography in patients with glaucoma and healthy subjects. Br J Ophthalmol; Published Online First: 27 February 2020. http://dx.doi.org/10.1136/bjophthalmol-2019-315592

Smith CA, Hooper ML, Chauhan BC. Optical coherence tomography angiography in mice: Quantitative analysis after experimental models of retinal damage. Invest Ophthalmol Vis Sci 2019;60(5):1556-1565. https://doi.org/10.1167/iovs.18-26441  

Smith CA, Chauhan BC. In vivo imaging of adeno-associated viral vector labelled retinal ganglion cells. Sci Rep 2018;8:1490. http://dx.doi.org/10.1038/s41598-018-19969-9  

Smith CA, Vianna JR, Chauhan BC. Assessing retinal ganglion cell damage. Eye 2017;31(2):209-217. https://dx.doi.org/10.1038/eye.2016.295  

Smith CA, Chauhan BC. Imaging retinal ganglion cells: Enabling experimental technology for clinical application. Prog Retin Eye Res 2015;44:1-14. http://dx.doi.org/10.1016/j.preteyeres.2014.10.003

Smith CA, Newson TA, Hutnik CML, Hill KA. Identification of anomalous features of intravitreal injections using micro-computed tomography. Curr Eye Res 2013;38:375-380. http://dx.doi.org/10.3109/02713683.2012.744059

Smith CA, Newson TA, Leonard KC, Barfett J, Holdsworth DW, Hutnik CML, Hill KA. A novel framework for modeling ocular drug transport and flow through the eye using micro-CT. Phys Med Biol 2012;57(19):6295-6307. http://dx.doi.org/10.1088/0031-9155/57/19/6295

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