COREY A. SMITH, PhD

The goal of my research program is to provide new insight into retinal diseases using ophthalmic imaging. Specifically, I use innovative acquisition and processing methods to obtain and extract new information from imaging data. This field of research is important to ensure imaging devices are used to the best of their potential for improved patient care when diagnosing, treating, and monitoring retinal diseases. Two important priorities for my research program are:

1. Creating a diverse research group with multi-disciplinary collaborations
2. Research that is a balance of experimental methods and clinical relevance

Research Opportunities: Trainees/students interested in research opportunities should send a summary of their interests and their CV to corey.smith@dal.ca. We will work with trainees to develop strong proposals for scholarship and fellowship applications.

Patient Partners (coming soon)

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Brianna Samson

Masters Student - Biomedical Engineering

Colyn Munn

Masters Student - Biomedical Engineering

Sebastiaan Oosthuizen

Medical Sciences Honours Student

Hodgson K, Palakkamanil MM, Zhang A, Dyachok OM, Smith CA, Nicolela MT, Chauhan BC. Effect of ginkgo biloba extract on macula and peripapillary perfusion examined using optical coherence tomography angiography. Can J Ophthalmol 2025 In press. https://doi.org/10.1016/j.jcjo.2025.01.015

Tomita R, Smith CA, Dyachok OM, Sharpe GP, Rafuse PE, Shuba LM, Nicolela MT, Chauhan BC. Sequence and detectability of changes in macular ganglion cell layer thickness and perfusion density in early glaucoma. Invest Ophthalmol Vis Sci 2024 Dec 2;65(14):8. https://doi.org/10.1167/iovs.65.14.8

Smith CA, Josey VL, West ME, Dyachok OM, Sharpe GM, Vianna JR, Rafuse PE, Shuba LM, Nicolela MT, Chauhan BC. Variability of scan quality and perfusion density in longitudinal optical coherence tomography angiography imaging. Br J Ophthalmol 2024 Jun 20;108(7):978-983. https://doi.org/10.1136/bjo-2022-322979

Pollmann AS, Pinto AM, Cadieux D, Seamone CD, George SP, Smith CA, Leiws DR. Association Between Indication for Descemet Stripping Automated Endothelial Keratoplasty and Rural Residency. Cornea 2024 Mar 1;43(3):349-355. https://doi.org/10.1097/ico.0000000000003347

Eadie BD, Mishra AV, Betsch DM, Smith CA, Nicolela MT, Chauhan BC. Transsynaptic vascular hypoperfusion in the retina of a patient with post-chiasmal lesion and homonymous hemianopia. J Neuroophthalmol 2023 Dec 1;43(4):e349-e351. https://doi.org/10.1097/wno.0000000000001733

Ruparelia S, Orr S, Choudhry N, Wong RW, Smith CA, Taylor SM, Gupta RR. Risk for surgical team hearing loss with vitrectomy. J Vitreoretin Dis 2023;Sept-Oct;7(5):397-403. https://doi.org/10.1177/24741264231172564

Di Pierdomenico J, Henderson DCM, Giammaria S, Smith VL, Jamet AJ, Smith CA, Hooper ML, Chauhan BC. Age and intraocular pressure in murine experimental glaucoma. Prog Ret Eye Res 2022 May;88:101021. https://doi.org/10.1016/j.preteyeres.2021.101021

Hirasawa K, Smith CA, West ME, Sharpe GP, Shuba LM, Rafuse PE, Nicolela MT, Vianna JR, Chauhan BC. Discrepancy in loss of macular perfusion density and ganglion cell thickness in early glaucoma. Am J Ophthalmol 2021;221:39-47. https://doi.org/10.1016/j.ajo.2020.08.031

Duggan E, Smith CA, Hooper ML, Chauhan BC. Colocalization of optical coherence tomography angiography with histology in the mouse retina. Microvasc Res; Published Online First: 8 August 2020. https://doi.org/10.1016/j.mvr.2020.104055

Hanna V, Sharpe GP, West ME, Hutchison DM, Shuba LM, Rafuse PE, Nicolela MT, Smith CA, Chauhan BC. Peripapillary retinal segmentation in optical coherence tomography angiography. Ophthalmology 2020;127(12):1770-1772. https://doi.org/10.1016/j.ophtha.2020.05.032

Smith CA, West ME, Sharpe GP, Hutchison DM, Shuba LM, Rafuse PE, Nicolela MT, Chauhan BC. Asymmetry analysis of macular optical coherence tomography angiography in patients with glaucoma and healthy subjects. Br J Ophthalmol 2020;104(12):1724-1729. http://dx.doi.org/10.1136/bjophthalmol-2019-315592

Smith CA, Hooper ML, Chauhan BC. Optical coherence tomography angiography in mice: Quantitative analysis after experimental models of retinal damage. Invest Ophthalmol Vis Sci 2019;60(5):1556-1565. https://doi.org/10.1167/iovs.18-26441  

Smith CA, Chauhan BC. In vivo imaging of adeno-associated viral vector labelled retinal ganglion cells. Sci Rep 2018;8:1490. http://dx.doi.org/10.1038/s41598-018-19969-9  

Smith CA, Vianna JR, Chauhan BC. Assessing retinal ganglion cell damage. Eye 2017;31(2):209-217. https://dx.doi.org/10.1038/eye.2016.295  

Smith CA, Chauhan BC. Imaging retinal ganglion cells: Enabling experimental technology for clinical application. Prog Retin Eye Res 2015;44:1-14. http://dx.doi.org/10.1016/j.preteyeres.2014.10.003

Smith CA, Newson TA, Hutnik CML, Hill KA. Identification of anomalous features of intravitreal injections using micro-computed tomography. Curr Eye Res 2013;38:375-380. http://dx.doi.org/10.3109/02713683.2012.744059

Smith CA, Newson TA, Leonard KC, Barfett J, Holdsworth DW, Hutnik CML, Hill KA. A novel framework for modeling ocular drug transport and flow through the eye using micro-CT. Phys Med Biol 2012;57(19):6295-6307. http://dx.doi.org/10.1088/0031-9155/57/19/6295

Click here to view PubMed entries for Corey A. Smith